The revelation of Hiromi and Shinichiro being half-siblings will turn out to be false, they will end up together.
Noe will die due to a not-yet-mentioned disease, but her quest will regain her tears will be completed as she lays on her death bed. The tears will come from Shinichiro, whose heartfelt crying will touch Noe and leave her happy and content as she fades away.
Aiko will ultimately end up back with Miyokichi, after an incident in which he saves her from being molested by a stranger, an accidental fire that leaves her trapped in her store, or some other extraordinary event.
Number 4 crashes his bike into a rice paddy.