Yes, it did.
Gainax stated that Simon was the strongest person in the universe, and because of this if he continued fighting he would have caused the spiral nemesis.
And in the GL novels, it's said that the Anti-Spiral gene is only in the most beautiful humans, which is why Genome had a harem of the most beautiful women, so that if they were to have children he could abandon them without them turning into Anti-Spiral Messengers. Nia had the A-S DNA in her, and it was her that became the Anti-Spiral Messenger, so she's the most beautiful person on Earth.
THIS, OF COURSE, ALSO EXPLAINS WHY SHE IS SO SIMILAR TO NONO, BECAUSE NONO IS BEAUTIFUL AND PERFECT.