Hohenheim in the manga is way more fucking awesome than the anime. Almost every character that was kind of a pussy or whiner in the anime has their head together in the manga.
Hell Marcoh had one of the best scenes in the series so far.
The tone of the manga, while not going into that stupid otherside of the gate is our world tripe, is on a far grander scale. Plus you get to see more of the others rather than just Ed and Al.
Even Rose is better in the manga.