I'd probably say the best feature about anime is how the perspective is not reliant on looking for set locations to film a particular sequence, which means it can be drawn at the correct angle to give off the ideal atmosphere. My favorite examples of this include a sequence in the first Patlabor film in which a chief yells at his subordinate (Ota) and the angle focuses almost concave-like upon his face and then shifts the perspective slightly as the argument becomes heated. Another sequence, ironically Patlabor 2, has a montage of troops surrounding Tokyo with many angles that would be hard to capture in a conventional live-action film such as reflective skyscrapers that capture a chopper riding by for instance.
Another possible benefit, though it can certainly be a double-edged sword, is the violence and destruction that can be depicted. Entire buildings can be destroyed effortlessly, people can practically explode if the artists desired it, and the whole planet could just freaking blow up if it was desired. Of course, once again, violence destruction is good and bad.
Designs such as mechs or fantasy-themed creatures are made with relative ease, without the worry for makeup or special effects (in some cases) to cover the visual look. So this aspect is easier.
Finally, overall content. I'd be totally surprised if most anime could be translated accurately into live-action. Some can, but some can't. Just look at material like Project A-ko or FLCL for instance.