It's essentially a magical girl team show, like Powerpuff Girls and what have you, except instead of magic or science it's specialty psychic powers. The plots are pretty much what you would expect from something like that.
I guess the underlying theme that's a little atypical of the genre is discrimination against people with psychic powers and the effect it has on the girls. At least in what little of the manga I've read, their organization BABEL is concerned about whether or not they'll grow up to be heroes or villians due to their powers, since they have a tendency to be spoiled bitches and are somewhat aware that given the motive, their high-level abilities would allow them to get away with pretty much anything.
Otherwise, monster-of-the-week as sent by effeminate bad guy.