The series will end up with her dying, probably from some disease. In the end she'll reveal that she just wanted to improve him as a person. At the end she'll say she truly loves him, but by then she will be basically dead. After her death he will move on and become more confident of himself, instead of being such a loser faggot.
To be honest though, the series is really great. It has the same kind of feeling NHK did, but better in my opinion. Maybe because the changes going through the character aren't being expressed as major plot points in the story.