I'm ashamed to say that I've only read two Tezuka works so far: Ode to Kirihito and Metropolis.
I like the movie version of Metropolis but didn't like the manga. It was too silly for my tastes and I didn't get particularly attached to the story. Then again, it's an early work and it's not particularly long.
I definitely recommend Kirihito though. I've also heard that MW is along the same lines though slightly darker. I've also heard good things about Phoenix and Buddha.