The story of Gurren Lagann is a perfect metaphor for what has happened in South Africa.
The humans (whites), were the rightful rulers of Earth, ensuring the natural order of things and the safety and welfare of all lesser creatures, ruling with fairness and keeping the land bright and prosperous.
Yet, one day, Lord Genome (the old establishment) was killed, and the heir to the throne, Simon (the new, younger generation of whites), was convinced that all the problems on Earth were his fault (white guilt), and so he was forced to leave Kamina City, ashamed.
The responsible for brainwashing Simon was his friend Rossiu (representing communists, liberals, jews, foreign governments), who told him that everything was his fault, and took power once the rightful heir had left in shame.
With Simon in exile and apathetic (just like white south africans that no longer get involved in politics or have left the country altogether), Rossiu allowed the beastmen (black criminals) to rule unoppressed, raping and plundering the land. The once prosperous Kamina City went into decay, and became a dark, unforgiving place with no order or peace, only death and criminality.
If the story of Gainax is to be held true, one day the whites will wake up from this lie, and will reclaim their role as the rightful rulers of Earth, restoring order, peace, and welfare for them and all the lesser creatures that inhabit this Earth.