The Big O premiered on October 13, 1999. The show was not a hit in its native Japan, rather it was reduced from an outlined 26 episodes to 13 episodes. Western audiences were more receptive and the series achieved the success its creators were looking for. In an interview with AnimePlay Magazine, Keiichi Sato said "This is exactly as we had planned", referring to the success overseas.
The Big O's most commented upon influence is DC Comics' Batman. Sunrise, the series production studio, was a subcontractor for Warner Bros. Animation's Batman: The Animated Series, and Toonami promos acknowledged the Dark Knight's influence on Roger Smith.
It was pretty much aim at the western audience. You should be able to enjoy it unless you are a big weeaboo. In that case shoot yourself.