No. Not Fran.
Maybe you think you are raping her, but in fact you are actually having sex your aunts vagina she wears like a second pair of pants.
I mean fucks sake, she has 6 arms, how are you gonna rape that?
was it 6 or 4? idk.
And i know for a fact she always carries a dissection kit.
whats more she knows every nerve in the human body INTRICATLEY.
then considering her knowledge of chemicals and physiology I doubt you could knock her out with gas/chloraform.
Oh yeah and she has an army of monsters.