I think it could be pulled off. Hamlet's interpretations have changed so radically since its authorship that you could find support for a comparison to damn near anything somewhere. Even stupid giant robot or lesbian helicopter animu. And with all Simoun's girls with various brooding internal conflicts having to do with their religion and (insert "so beautiful I want to punch people in the face" rant) and putting off maturation much like Hamlet procrastinated to act, I can see something that could be teased out already.
Not by me, I don't have the energy. But oh man would that piss people off, it's making me mad at the pretentious douchebag voice in my head just thinking about it