Stop failing by bringing Azumanga Daioh each time we talk about LS.
The only things they have in common is settings : highschool, slice-of-life, young girls.
After that...they don't have the same humor, neither the same audience.
But the first one have a slow storytelling, slow jokes and is quite "safe".
The second is much more aimed to otaku-like, and in general, a certain public. There is strong mention of "hentai", "yaoi", "yuri", "lolicon" in it. There's also video-games and MMO jokes.
Ultimately, the perfect representant of the LS fanbase is certainly a TOUHOU fag.