One of the problems is that an intrinsic part of Kaiji's games is that people need to have a huge amount riding on the game so that they're motivated to play crazy. So long as you had people playing a set-up where, let's say, if you lose then instead of going to 'the room' a virus is downloaded to your computer that completely destroys it... then you'd have people doing crazy mindgames and politics and double-crosses and shit. That shit would be cash as hell.
But yeah, it'd be much easier to just do some sort of IRL INSANE GAMBLE with it. I've definitely been thinking about what I have that I could gamble with.