Yes, it's markedly different in some respects. Akiha actually fights Ciel, Shiki looks sort of Nanaya on more than just two occasions, SHIKIROA is actually sort of badass, Arcueid is even more moe, and there's slightly better plot pacing. Ciel is actually sort of cool, too.
The only bad part is that it's Far Side and we don't get to see much on the Near Side, especially with the mAIDS.
I really like how they've done the Shiki remembering all of the shit from his past, though. Getting to see SHIKI as his friend instead of just an inverted demonic bastard was good. It was the equivalent of the conversation under the moon in Kagetsu Tohya. You find out he was actually a good friend and cared about Akiha.
The only thing we haven't found out is how this thing will end. It will either be brickshitting or lame. There is no middle ground.