How much can good topology be milked?

No.497424 ViewReplyOriginalReport
I don't have much experience with rigging models (not much = 0), but I consider myself pretty good with mesh topology.
However, I'm also lazy, so I ask this question: With the right mesh topology and rigging, would it be possible for me to make two completely different characters just by moving the bones of one mesh, and doing a small amount of sculpting?
Since the bone structures of all mammals seems to be fundamentally the same, of course...